The Moon
NASA has assembled a panel of 4 experts to examine our national vision for space exploration, including the current plans to establish a permanent base on the moon, and then go on to Mars.
Mars
Opportunity has gotten the first glimpse of the rim of endeavor crater, still 12 km and just about 2 years away:
Also, NASA is hosting a contest to name the new Mars rover (ie MSL)
Deep space
New Horizons is now 1/3 of the way to Pluto (by distance)
DSR 2.5